Gene
tirap
- ID
- ZDB-GENE-040219-4
- Name
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- Symbol
- tirap Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable Toll-like receptor 2 binding activity and Toll-like receptor 4 binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction; positive regulation of cytokine production; and toll-like receptor 4 signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
|---|---|---|---|---|
|
UniProtKB:A0A8M6Z2S6
|
243 | |||
|
UniProtKB:A0A8M1REJ6
|
226 |
1 - 2 of 2
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available