Gene
ticam1
- ID
- ZDB-GENE-040219-2
- Name
- TIR domain containing adaptor molecule 1
- Symbol
- ticam1 Nomenclature History
- Previous Names
-
- trif (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable signaling adaptor activity. Acts upstream of or within positive regulation of canonical NF-kappaB signal transduction and positive regulation of interferon-beta production. Located in Golgi apparatus. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in brain disease. Orthologous to several human genes including TICAM1 (TIR domain containing adaptor molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ticam1 | Zebrafish Nomenclature Committee | |
| MO1-ticam1 | N/A | Liang et al., 2024 |
1 - 2 of 2
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 6} | 614850 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | TIR domain-containing adapter molecule 1/2 | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily | TRIF, N-terminal |
|---|---|---|---|---|---|---|
| UniProtKB:Q1LUQ2 | InterPro | 566 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ticam1-201
(1)
|
Ensembl | 2,318 nt | ||
| mRNA |
ticam1-202
(1)
|
Ensembl | 1,947 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-124A3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162016 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044759 (1) | 2318 nt | ||
| Genomic | GenBank:BX927276 (1) | 166844 nt | ||
| Polypeptide | UniProtKB:Q1LUQ2 (1) | 566 aa |
- Liang, H., Li, M., Chen, J., Zhou, W., Xia, D., Ding, Q., Yang, Y., Zhang, Z., Ran, C., Zhou, Z. (2024) The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish. Microbiome. 12:244244
- Tang, H.P., Huang, C., Hu, C.B., Li, H., Shao, T., Ji, J.F., Bai, J., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2021) Inhibitory Role of an Aeromonas hydrophila TIR Domain Effector in Antibacterial Immunity by Targeting TLR Signaling Complexes in Zebrafish. Frontiers in microbiology. 12:694081
- Lu, Z., Cao, H., Liu, D., Zheng, Y., Tian, C., Liu, S., Quan, J., Shi, L., Liu, J., Yu, L. (2020) Optimal combination of anti-inflammatory components from Chinese medicinal formula Liang-Ge-San. Journal of ethnopharmacology. 269:113747
- Chen, M., Luo, Y., Xu, J., Chang, M.X., Liu, J.X. (2019) Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. Frontiers in immunology. 10:2599
- Liu, J., Wei, T., Wu, X., Zhong, H., Qiu, W., Zheng, Y. (2019) Early exposure to environmental levels of sulfamethoxazole triggers immune and inflammatory response of healthy zebrafish larvae. The Science of the total environment. 703:134724
- Luo, L., Zhou, J., Zhao, H., Fan, M., Gao, W. (2019) The anti-inflammatory effects of formononetin and ononin on lipopolysaccharide-induced zebrafish models based on lipidomics and targeted transcriptomics. Metabolomics : Official journal of the Metabolomic Society. 15:153
- Zhang, Y., Takagi, N., Yuan, B., Zhou, Y., Si, N., Wang, H., Yang, J., Wei, X., Zhao, H., Bian, B. (2019) The protection of indolealkylamines on LPS-induced inflammation in zebrafish. Journal of ethnopharmacology. 243:112122
- Dong, X., Zhang, Z., Meng, S., Pan, C., Yang, M., Wu, X., Yang, L., Xu, H. (2018) Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity. The Science of the total environment. 610-611:291-297
- Duan, J., Liang, S., Feng, L., Yu, Y., Sun, Z. (2018) Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro. International Journal of Nanomedicine. 13:7303-7318
- Wei, J., Zhou, T., Hu, Z., Li, Y., Yuan, H., Zhao, K., Zhang, H., Liu, C. (2018) Effects of triclocarban on oxidative stress and innate immune response in zebrafish embryos. Chemosphere. 210:93-101
1 - 10 of 34
Show