Gene

tlr5a

ID
ZDB-GENE-040219-14
Name
toll-like receptor 5a
Symbol
tlr5a Nomenclature History
Previous Names
  • TIR5a (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable signaling receptor activity. Acts upstream of or within activation of immune response and toll-like receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tlr5a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Legionnaire disease, susceptibility to} 608556
{Melioidosis, susceptibility to} 615557
{Systemic lupus erythematosus, resistance to} 601744
{Systemic lupus erythematosus, susceptibility to, 1} 601744
Associated With tlr5a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Domain IPR000483 Cysteine-rich flanking region, C-terminal
Family IPR017241 Toll-like receptor
Family IPR027176 Toll-like receptor 5
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Repeat IPR026906 BspA type Leucine rich repeat region
Domain Details Per Protein
Protein Length BspA type Leucine rich repeat region Cysteine-rich flanking region, C-terminal Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype Toll/interleukin-1 receptor homology (TIR) domain Toll/interleukin-1 receptor homology (TIR) domain superfamily Toll-like receptor Toll-like receptor 5
UniProtKB:F8W4F1 881
UniProtKB:Q6TQH8 187
UniProtKB:A0A2R3VHL5 881
UniProtKB:U3JAP9 42
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations