Gene
tlr8a
- ID
- ZDB-GENE-040219-13
- Name
- toll-like receptor 8a
- Symbol
- tlr8a Nomenclature History
- Previous Names
-
- TIR8.2 (1)
- Type
- protein_coding_gene
- Location
- Unmapped
- Description
- Predicted to have DNA binding activity; RNA binding activity; and transmembrane signaling receptor activity. Predicted to be involved in several processes, including defense response to other organism; regulation of cytokine secretion; and toll-like receptor signaling pathway. Predicted to localize to integral component of membrane. Is expressed in blood; heart; liver; and pleuroperitoneal region. Orthologous to human TLR8 (toll like receptor 8).
- Genome Resources
-
- Alliance (1)
- Gene:403137 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu791 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Immunodeficiency 98 with autoinflammation, X-linked | 301078 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
| Repeat | IPR026906 | BspA-type LRR region |
Domain Details Per Protein
| Protein | Length | BspA-type LRR region | Cysteine-rich flanking region, C-terminal | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1QHF1
|
1019 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance