Gene

tlr7

ID
ZDB-GENE-040219-11
Name
toll-like receptor 7
Symbol
tlr7 Nomenclature History
Previous Names
  • TLR7A (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have single-stranded RNA binding activity and transmembrane signaling receptor activity. Predicted to be involved in defense response to other organism; inflammatory response; and toll-like receptor signaling pathway. Predicted to localize to cytoplasm; cytoskeleton; and integral component of membrane. Is expressed in several structures, including blood; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tlr7 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
X-Linked immunodeficiency 74 Alliance Immunodeficiency 74, COVID19-related, X-linked 301051
Associated With tlr7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Domain IPR000299 FERM domain
Domain IPR000483 Cysteine-rich flanking region, C-terminal
Domain IPR001202 WW domain
Domain IPR001478 PDZ domain
Domain IPR019748 FERM central domain
Domain IPR019749 Band 4.1 domain
Domain IPR041779 FERM and PDZ domain-containing protein 1/3/4, FERM domain C-lobe
Family IPR017241 Toll-like receptor
Family IPR026880 Toll-like receptor 7
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR014352 FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
Homologous_superfamily IPR035963 FERM superfamily, second domain
Homologous_superfamily IPR036034 PDZ superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Domain Details Per Protein
Protein Length Band 4.1 domain Cysteine-rich flanking region, C-terminal FERM/acyl-CoA-binding protein superfamily FERM and PDZ domain-containing protein 1/3/4, FERM domain C-lobe FERM central domain FERM domain FERM superfamily, second domain Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype PDZ domain PDZ superfamily PH-like domain superfamily Toll/interleukin-1 receptor homology (TIR) domain Toll/interleukin-1 receptor homology (TIR) domain superfamily Toll-like receptor Toll-like receptor 7 Ubiquitin-like domain superfamily WW domain
UniProtKB:F1QY64 1045
UniProtKB:Q6TQH6 206
UniProtKB:F1QXP3 1221
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations