Gene

tlr7

ID

ZDB-GENE-040219-11

Name

toll-like receptor 7

Symbol

tlr7 Nomenclature History

Previous Names

TLR7A (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have single-stranded RNA binding activity and transmembrane signaling receptor activity. Predicted to be involved in defense response to other organism and toll-like receptor signaling pathway. Predicted to localize to cytoskeleton and integral component of membrane. Is expressed in several structures, including blood; heart; integument; liver; and pleuroperitoneal region. Orthologous to human TLR7 (toll like receptor 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tlr7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
X-Linked immunodeficiency 74	Alliance	Immunodeficiency 74, COVID19-related, X-linked	301051
		Systemic lupus erythematosus 17	301080

Associated With tlr7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Domain	IPR000483	Cysteine-rich flanking region, C-terminal
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype

Domain Details Per Protein

Protein	Length	Cysteine-rich flanking region, C-terminal	Leucine-rich repeat	Leucine-rich repeat domain superfamily	Leucine-rich repeat, typical subtype	Toll/interleukin-1 receptor homology (TIR) domain	Toll/interleukin-1 receptor homology (TIR) domain superfamily
UniProtKB:A0A8M9QKF3 InterPro	1036

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tlr7-201 (1) Ensembl	Ensembl		3,138 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations