sarm1

ID

ZDB-GENE-040219-1

Name

sterile alpha and TIR motif containing 1

Symbol

sarm1 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables NAD+ nucleosidase activity. Involved in NAD catabolic process. Acts upstream of or within regulation of axon regeneration. Predicted to be located in axon; mitochondrion; and synapse. Predicted to be active in dendrite. Is expressed in posterior lateral line and spinal cord. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sarm1 Human Ortholog

No data available

Associated With sarm1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Domain	IPR001660	Sterile alpha motif domain
Family	IPR039184	Sterile alpha and TIR motif-containing protein 1
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily