Gene

tal2

ID

ZDB-GENE-040115-1

Name

T-cell acute lymphocytic leukemia 2

Symbol

tal2 Nomenclature History

Previous Names

zgc:111884

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development and ventral spinal cord interneuron differentiation. Is expressed in floor plate; neurons; and spinal cord. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and adult T-cell leukemia/lymphoma. Orthologous to human TAL2 (TAL bHLH transcription factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Yang et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tal2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute lymphoblastic leukemia	Alliance	Leukemia, T-cell acute lymphocytic, somatic	613065

Associated With tal2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Family	IPR040238	Helix-loop-helix protein TAL-like
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily