Gene

fa2h

ID
ZDB-GENE-031219-4
Name
fatty acid 2-hydroxylase
Symbol
fa2h Nomenclature History
Previous Names
  • cb1044 (1)
  • zgc:153777
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have fatty acid alpha-hydroxylase activity. Predicted to be involved in fatty acid metabolic process. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Is expressed in EVL; digestive system; ectoderm; peripheral olfactory organ; and pronephric duct. Orthologous to human FA2H (fatty acid 2-hydroxylase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2001
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fa2h Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spastic paraplegia 35 Alliance Spastic paraplegia 35, autosomal recessive 612319
Associated With fa2h Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018506 Cytochrome b5, heme-binding site
Domain IPR001199 Cytochrome b5-like heme/steroid binding domain
Domain IPR006694 Fatty acid hydroxylase
Family IPR014430 Sterol desaturase Scs7
Homologous_superfamily IPR036400 Cytochrome b5-like heme/steroid binding domain superfamily
Domain Details Per Protein
Protein Length Cytochrome b5, heme-binding site Cytochrome b5-like heme/steroid binding domain Cytochrome b5-like heme/steroid binding domain superfamily Fatty acid hydroxylase Sterol desaturase Scs7
UniProtKB:F1R936 377
UniProtKB:A0A2R8QGN1 249
UniProtKB:Q0P3V8 102
UniProtKB:A0A0R4IRD3 106
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations