Gene

gpc3

ID
ZDB-GENE-031212-1
Name
glypican 3
Symbol
gpc3 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Involved in cell migration involved in gastrulation and negative regulation of canonical Wnt signaling pathway. Predicted to localize to anchored component of plasma membrane; cell surface; and extracellular region. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Is expressed in intestine; liver; and midbrain. Orthologous to human GPC3 (glypican 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gpc3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nephroblastoma Alliance Wilms tumor, somatic 194070
Simpson-Golabi-Behmel syndrome type 1 Alliance Simpson-Golabi-Behmel syndrome, type 1 312870
Associated With gpc3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001863 Glypican
Family IPR015501 Glypican-3
Domain Details Per Protein
Protein Length Glypican Glypican-3
UniProtKB:Q6V9Y8 590
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations