Gene
dock2
- ID
- ZDB-GENE-031125-1
- Name
- dedicator of cytokinesis 2
- Symbol
- dock2 Nomenclature History
- Previous Names
-
- cb1005 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in macrophage. Orthologous to human DOCK2 (dedicator of cytokinesis 2).
- Genome Resources
-
- Alliance (1)
- Gene:571408 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1005 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 40 | Alliance | Immunodeficiency 40 | 616433 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR027357 | DOCKER domain |
| Domain | IPR046769 | DOCKER, Lobe A |
| Domain | IPR046770 | DOCKER, Lobe B |
| Domain | IPR046773 | DOCKER, Lobe C |
| Family | IPR026791 | Dedicator of cytokinesis |
| Homologous_superfamily | IPR043161 | Dedicator of cytokinesis, C-terminal, lobe A |
| Homologous_superfamily | IPR043162 | Dedicator of cytokinesis, C-terminal, lobe C |
Domain Details Per Protein
| Protein | Length | Dedicator of cytokinesis | Dedicator of cytokinesis, C-terminal, lobe A | Dedicator of cytokinesis, C-terminal, lobe C | DOCKER domain | DOCKER, Lobe A | DOCKER, Lobe B | DOCKER, Lobe C |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1RM83
|
678 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance