ZFIN is now using GRCz12tu for Genomic Data
Gene
dock2
- ID
- ZDB-GENE-031125-1
- Name
- dedicator of cytokinesis 2
- Symbol
- dock2 Nomenclature History
- Previous Names
-
- cb1005 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within small GTPase-mediated signal transduction. Is expressed in macrophage. Human ortholog(s) of this gene implicated in immunodeficiency 40. Orthologous to human DOCK2 (dedicator of cytokinesis 2).
- Genome Resources
-
- Alliance (1)
- Gene:100330200 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1005 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 40 | Alliance | Immunodeficiency 40 | 616433 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M1RM83 | InterPro | 678 |
| UniProtKB:A0AC58H981 | InterPro | 1827 |
| UniProtKB:A0AC58H993 | InterPro | 1747 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance