ZFIN ID: ZDB-GENE-031117-1
Gene Name: recombination signal binding protein for immunoglobulin kappa J region a
Gene Symbol: rbpja    Nomenclature History

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Previous Names: rbpj (1), ik:tdsubc_1e8, rbpsuh (1), Su(H)1 (1), Su(H) (1), tdsubc_1e8, xx:tdsubc_1e8

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II repressing transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including animal organ development; blood vessel development; and embryonic pattern specification. Predicted to localize to MAML1-RBP-Jkappa- ICN1 complex; nucleus; and transcription factor complex. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Is expressed in head; midbrain; and otic vesicle. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region).
Genome Resources: Alliance (1),  Gene:386772 (1),  Ensembl(GRCz11):ENSDARG00000003398 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013570Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la013571Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-rbpja
    1
    MO1-rbpja N/A 5
    MO3-rbpja N/A 2
    MO4-rbpja,rbpjb N/A 32
    MO5-rbpja,rbpjb N/A 4
    MO6-rbpja N/A 1
    DISEASE ASSOCIATED WITH rbpja HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Adams-Oliver syndrome Alliance Adams-Oliver syndrome 3 614814
    DISEASE ASSOCIATED WITH rbpja VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adrenal gland development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rbpja
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(HSE:GFP,dnrbpja-MYC) GFPrbpja Danio rerio 1 3
    Tg(mitfa:TETA-GBD,TETRE:NLS-Venus-2A-dnrbpja) mitfaTETRE 2ANLSrbpjaTETA-GBDVenus Danio rerio 1 1
    Tg(QUAS:NLS-Venus-2A-dnrbpja) QUAS 2ANLSrbpjaVenus Danio rerio 1 2
    MARKER RELATIONSHIPS
    rbpja Encodes: [EST] tdsubc_1e8
    [cDNA] MGC:195350 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_198878 (1) 1871 nt
    Polypeptide UniProtKB:Q6YLA3 (1) 498 aa
    Sequence Information (all 18)
    ORTHOLOGY for rbpja ( Chr: 1 )
    CITATIONS (74)