Gene
pld1a
- ID
- ZDB-GENE-031002-2
- Name
- phospholipase D1a
- Symbol
- pld1a Nomenclature History
- Previous Names
-
- pld1
- si:ch211-244m8.2
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables phospholipase D activity. Acts upstream of or within angiogenesis. Predicted to be located in endomembrane system. Predicted to be active in cytoplasmic vesicle and plasma membrane. Is expressed in liver; notochord; pharyngeal pouch; and somite. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Zeng et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6842 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11536 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19763 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38333 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39837 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pld1a | N/A | Zeng et al., 2009 |
| MO2-pld1a | N/A | Zeng et al., 2009 |
| MO3-pld1a | N/A | Zeng et al., 2009 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental cardiac valvular defect | Alliance | Cardiac valvular dysplasia 1 | 212093 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PH-like domain superfamily | Phospholipase D, eukaryotic type | Phospholipase D family | Phospholipase D-like domain | Phospholipase D/Transphosphatidylase | Phox homology | Pleckstrin homology domain | PX domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0V1J1 | InterPro | 1022 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-244M8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001160095 (1) | 4461 nt | ||
| Genomic | GenBank:CR848726 (2) | 155462 nt | ||
| Polypeptide | UniProtKB:B0V1J1 (1) | 1022 aa |
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, Y., Lu, Y., Zhang, Y., Ning, Z., Li, Y., Zhao, Q., Lu, H., Huang, R., Xia, X., Feng, Q., Liang, X., Liu, K., Zhang, L., Lu, T., Huang, T., Fan, D., Weng, Q., Zhu, C., Lu, Y., Li, W., Wen, Z., Zhou, C., Tian, Q., Kang, X., Shi, M., Zhang, W., Jang, S., Du, F., He, S., Liao, L., Li, Y., Gui, B., He, H., Ning, Z., Yang, C., He, L., Luo, L., Yang, R., Luo, Q., Liu, X., Li, S., Huang, W., Xiao, L., Lin, H., Han, B., Zhu, Z. (2015) The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation. Nature Genetics. 47(6):625-31
- Ulloa, P.E., Peña, A.A., Lizama, C.D., Araneda, C., Iturra, P., Neira, R., and Medrano, J.F. (2013) Growth response and expression of muscle growth-related candidate genes in adult zebrafish fed plant and fishmeal protein-based diets. Zebrafish. 10(1):99-109
- Liu, H.Y., Lee, N., Tsai, T.Y., and Ho, S.Y. (2010) Zebrafish fat-free, a novel Arf effector, regulates phospholipase D to mediate lipid and glucose metabolism. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1801(12):1330-1340
- Zeng, X.X., Zheng, X., Xiang, Y., Cho, H.P., Jessen, J.R., Zhong, T.P., Solnica-Krezel, L., and Brown, H.A. (2009) Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish. Developmental Biology. 328(2):363-376
- Ghosh, S., Moore, S., Bell, R.M., and Dush, M. (2003) Functional analysis of a phosphatidic acid binding domain in human Raf-1 kinase : Mutations in the phosphatidate binding domain lead to tail and trunk abnormalities in developing zebrafish embryos. The Journal of biological chemistry. 278(46):45690-45696
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