Gene
egfra
- ID
- ZDB-GENE-030918-1
- Name
- epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
- Symbol
- egfra Nomenclature History
- Previous Names
-
- egfr
- erbb1a (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable epidermal growth factor binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in regulation of circadian sleep/wake cycle, sleep. Acts upstream of or within blood vessel lumenization. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct870 | Allele with one delins | Unknown | Unknown | CRISPR | |
| kg134 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | CRISPR | |
| la023699Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1683 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11905 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14931 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15365 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16195 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19660 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19661 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-egfra | Ciano et al., 2019 | |
| CRISPR2-egfra | (3) | |
| CRISPR3-egfra | Rahman et al., 2019 | |
| CRISPR4-egfra | (2) | |
| CRISPR5-egfra | Xue et al., 2023 | |
| MO1-egfra | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lung cancer | Alliance | Adenocarcinoma of lung, response to tyrosine kinase inhibitor in | 211980 |
| lung cancer | Alliance | Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in | 211980 |
| lung cancer | Alliance | {Nonsmall cell lung cancer, susceptibility to} | 211980 |
| Neonatal nephrocutaneous inflammatory syndrome | 616069 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Epidermal growth factor receptor, juxtamembrane domain | Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SZF7 | InterPro | 1191 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-221H17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-283M16 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-728C2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194806 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194424 (1) | 6169 nt | ||
| Genomic | GenBank:CR788232 (2) | 70979 nt | ||
| Polypeptide | UniProtKB:Q7SZF7 (1) | 1191 aa |
- Kang, Q., Jia, J., Dean, E.D., Yuan, H., Dai, C., Li, Z., Jiang, F., Zhang, X.K., Powers, A.C., Chen, W., Li, M. (2024) ErbB3 is required for hyperaminoacidemia-induced pancreatic α cell hyperplasia. The Journal of biological chemistry. 300(8):107499
- Li, C., Cai, R., Shi, W., Zhang, H., Liu, Z., Xie, F., Chen, Y., Hong, Q. (2024) Comparative transcriptome analysis of ovaries and testes reveals sex-biased genes and pathways in zebrafish. Gene. 901:148176
- Xue, N., Liu, X., Zhang, D., Wu, Y., Zhong, Y., Wang, J., Fan, W., Jiang, H., Zhu, B., Ge, X., Gonzalez, R.V.L., Chen, L., Zhang, S., She, P., Zhong, Z., Sun, J., Chen, X., Wang, L., Gu, Z., Zhu, P., Liu, M., Li, D., Zhong, T.P., Zhang, X. (2023) Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD. Nature communications. 14:12241224
- Cadiz Diaz, A., Schmidt, N.A., Yamazaki, M., Hsieh, C.J., Lisse, T.S., Rieger, S. (2022) Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2115009119
- Chen, W., Zhai, Y., Zhu, B., Wu, K., Fan, Y., Zhou, X., Liu, L., Ge, W. (2022) Loss of growth differentiation factor 9 causes an arrest of early folliculogenesis in zebrafish-A novel insight into its action mechanism. PLoS Genetics. 18:e1010318e1010318
- Sojan, J.M., Gundappa, M.K., Carletti, A., Gaspar, V., Gavaia, P., Maradonna, F., Carnevali, O. (2022) Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism. Frontiers in nutrition. 9:868805
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Wei, J., Wang, X., Dong, Y., Zhong, X., Ren, X., Song, R., Ma, J., Yu, A., Fan, Q., Yao, J., Shan, D., Lv, F., Zheng, Y., Deng, Q., Li, X., He, Y., Fan, S., Zhao, C., Wang, X., Yuan, R., She, G. (2022) Curcumae Rhizoma - combined with Sparganii Rhizoma in the treatment of liver cancer: Chemical analysis using UPLC-LTQ-Orbitrap MSn, network analysis, and experimental assessment. Frontiers in pharmacology. 13:10276871027687
- Yao, S., Zhou, X., Vona, B., Fan, L., Zhang, C., Li, D., Yuan, H., Du, Y., Ma, L., Pan, Y. (2022) Skeletal Class III Malocclusion Is Associated with ADAMTS2 Variants and Reduced Expression in a Familial Case. International Journal of Molecular Sciences. 23(18)
- Wang, K., Xu, Q., Zhong, H. (2021) The Bruton's Tyrosine Kinase Inhibitor Ibrutinib Impairs the Vascular Development of Zebrafish Larvae. Frontiers in pharmacology. 11:625498
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