Gene

egfra

ID

ZDB-GENE-030918-1

Name

epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

Symbol

egfra Nomenclature History

Previous Names

egfr
erbb1a (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in regulation of circadian sleep/wake cycle, sleep. Acts upstream of or within blood vessel lumenization. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Is expressed in several structures, including gill; liver; nervous system; pleuroperitoneal region; and somite. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 12 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With egfra Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lung cancer	Alliance	Adenocarcinoma of lung, response to tyrosine kinase inhibitor in	211980
lung cancer	Alliance	Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in	211980
lung cancer	Alliance	{Nonsmall cell lung cancer, susceptibility to}	211980
		Neonatal nephrocutaneous inflammatory syndrome	616069

Associated With egfra Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000494	Receptor L-domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR006211	Furin-like cysteine-rich domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR032778	Growth factor receptor domain 4
Domain	IPR049328	Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment
Family	IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
Family	IPR050122	Receptor Tyrosine Kinase
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036941	Receptor L-domain superfamily
Homologous_superfamily	IPR044912	Epidermal growth factor receptor, juxtamembrane domain
Repeat	IPR006212	Furin-like repeat

Domain Details Per Protein

Protein	Length	Epidermal growth factor receptor, juxtamembrane domain	Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment	Furin-like cysteine-rich domain	Furin-like repeat	Growth factor receptor cysteine-rich domain superfamily	Growth factor receptor domain 4	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Receptor L-domain	Receptor L-domain superfamily	Receptor Tyrosine Kinase	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine protein kinase, EGF/ERB/XmrK receptor
UniProtKB:Q7SZF7 InterPro	1191

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	egfra-201 (1) Ensembl	Ensembl	1,868 nt	Select Tool ZFIN BLAST
mRNA	egfra-202 (1) Ensembl	Ensembl	1,881 nt	Select Tool ZFIN BLAST
mRNA	egfra-203 (1) Ensembl	Ensembl	2,437 nt	Select Tool ZFIN BLAST
mRNA	egfra-205 (1) Ensembl	Ensembl	3,168 nt	Select Tool ZFIN BLAST
mRNA	egfra-206 (1) Ensembl	Ensembl	3,007 nt	Select Tool ZFIN BLAST
mRNA	egfra-207 (1) Ensembl	Ensembl	6,151 nt	Select Tool ZFIN BLAST
ncRNA	egfra-006 (1) Ensembl	Ensembl	518 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations