Gene

ggcx

ID

ZDB-GENE-030826-27

Name

gamma-glutamyl carboxylase

Symbol

ggcx Nomenclature History

Previous Names

cb751 (1)
si:ch1073-230p18.3
zgc:158736

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have gamma-glutamyl carboxylase activity and vitamin binding activity. Predicted to be involved in peptidyl-glutamic acid carboxylation. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in coagulation protein disease and inherited blood coagulation disease. Is expressed in several structures, including axis; digestive system; fin; otic placode; and polster. Orthologous to human GGCX (gamma-glutamyl carboxylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb751 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ggcx Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined deficiency of vitamin K-dependent clotting factors 1	Alliance	Vitamin K-dependent clotting factors, combined deficiency of, 1	277450
		Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency	610842

Associated With ggcx Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011020	HTTM
Family	IPR007782	Vitamin K-dependent gamma-carboxylase
Homologous_superfamily	IPR011051	RmlC-like cupin domain superfamily
Homologous_superfamily	IPR014710	RmlC-like jelly roll fold