Gene

ggcx

ID
ZDB-GENE-030826-27
Name
gamma-glutamyl carboxylase
Symbol
ggcx Nomenclature History
Previous Names
  • cb751 (1)
  • si:ch1073-230p18.3
  • zgc:158736
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable gamma-glutamyl carboxylase activity and vitamin binding activity. Predicted to be involved in vitamin K metabolic process. Predicted to act upstream of or within peptidyl-glutamic acid carboxylation. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including axis; digestive system; fin; otic placode; and polster. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 1. Orthologous to human GGCX (gamma-glutamyl carboxylase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ggcx Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined deficiency of vitamin K-dependent clotting factors 1 Alliance Vitamin K-dependent clotting factors, combined deficiency of, 1 277450
Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency 610842
1 - 2 of 2
Associated With ggcx Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011020 HTTM-like
Domain IPR053934 HTTM domain
Domain IPR053935 Vitamin K-dependent gamma-carboxylase, lumenal domain
Family IPR007782 Vitamin K-dependent gamma-carboxylase
Homologous_superfamily IPR011051 RmlC-like cupin domain superfamily
1 - 5 of 6 Show all
Domain Details Per Protein
Protein Additional Resources Length HTTM domain HTTM-like RmlC-like cupin domain superfamily RmlC-like jelly roll fold Vitamin K-dependent gamma-carboxylase Vitamin K-dependent gamma-carboxylase, lumenal domain
UniProtKB:A0A8M1RIV5 InterPro 770
1 - 1 of 1
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ggcx-201 (1) Ensembl 3,096 nt
mRNA ggcx-202 (1) Ensembl 1,342 nt
mRNA ggcx-203 (1) Ensembl 507 nt
mRNA ggcx-204 (1) Ensembl 477 nt
1 - 4 of 4
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations