Gene
tegt
- ID
- ZDB-GENE-030826-10
- Name
- testis enhanced gene transcript (BAX inhibitor 1)
- Symbol
- tegt Nomenclature History
- Previous Names
-
- BI-1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable calcium channel activity and endoribonuclease inhibitor activity. Predicted to be involved in cellular response to unfolded protein and negative regulation of apoptotic signaling pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human TMBIM6 (transmembrane BAX inhibitor motif containing 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6904793 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11859 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR006214 | Bax inhibitor 1-related |
Domain Details Per Protein
| Protein | Additional Resources | Length | Bax inhibitor 1-related |
|---|---|---|---|
| UniProtKB:A0A8M1RKH6 | InterPro | 236 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-387K14 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6904793 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009305712 (1) | 1496 nt | ||
| Genomic | GenBank:CU633745 (1) | 37310 nt | ||
| Polypeptide | UniProtKB:A0A8M1RKH6 (1) | 236 aa |
No data available
- Wu, S., Song, W., Wong, C.C.L., Shi, Y. (2019) Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 116:141147141-147
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
- Inohara, N. and Nuñez, G. (2000) Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell death and differentiation. 7(5):509-510
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