Gene
iars2
- ID
- ZDB-GENE-030616-608
- Name
- isoleucyl-tRNA synthetase 2, mitochondrial
- Symbol
- iars2 Nomenclature History
- Previous Names
-
- si:ch211-214p16.3 (1)
- si:zc214p16.3
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation and mitochondrial translation. Predicted to localize to mitochondrion. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148330 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia | 616007 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR002300 | Aminoacyl-tRNA synthetase, class Ia |
| Domain | IPR013155 | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding |
| Domain | IPR033708 | Isoleucyl tRNA synthetase type 1, anticodon-binding domain |
| Family | IPR002301 | Isoleucine-tRNA ligase |
| Family | IPR023585 | Isoleucine-tRNA ligase, type 1 |
| Family | IPR050081 | Isoleucine--tRNA ligase |
| Homologous_superfamily | IPR009008 | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain |
| Homologous_superfamily | IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class Ia | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding | Aminoacyl-tRNA synthetase, class I, conserved site | Isoleucine--tRNA ligase | Isoleucine-tRNA ligase | Isoleucine-tRNA ligase, type 1 | Isoleucyl tRNA synthetase type 1, anticodon-binding domain | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | Rossmann-like alpha/beta/alpha sandwich fold | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P8Q4
|
982 | ||||||||||
|
UniProtKB:F1QUQ0
|
983 |
Interactions and Pathways
No data available
Plasmids
No data available