ZFIN is now using GRCz12tu for Genomic Data
Gene
triob
- ID
- ZDB-GENE-030616-399
- Name
- trio Rho guanine nucleotide exchange factor b
- Symbol
- triob Nomenclature History
- Previous Names
-
- trio
- si:dz230d15.1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP binding activity; guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 44 and autosomal dominant intellectual developmental disorder 63 with macrocephaly. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1114 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 44 | Alliance | Intellectual developmental disorder, autosomal dominant 44, with microcephaly | 617061 |
| autosomal dominant intellectual developmental disorder 63 with macrocephaly | Alliance | Intellectual developmental disorder, autosomal dominant 63, with macrocephaly | 618825 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0AB32T2V7 | InterPro | 3022 |
| UniProtKB:A0AC58HIQ5 | InterPro | 1871 |
| UniProtKB:A0AC58HIR3 | InterPro | 1755 |
| UniProtKB:A0AC58HIR8 | InterPro | 1883 |
| UniProtKB:A0AC58HIS3 | InterPro | 2993 |
| UniProtKB:A0AC58HIS5 | InterPro | 3023 |
| UniProtKB:A0AC58HIT7 | InterPro | 3014 |
| UniProtKB:A0AC58HIU9 | InterPro | 2907 |
| UniProtKB:A0AC58HIV0 | InterPro | 3016 |
| UniProtKB:A0AC58HIW8 | InterPro | 3022 |
| UniProtKB:A0AC58HIX3 | InterPro | 3021 |
| UniProtKB:A0AC58HIX6 | InterPro | 1884 |
| UniProtKB:A0AC58HIX8 | InterPro | 3022 |
| UniProtKB:A0AC58HIZ1 | InterPro | 2994 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ottdart00000001996 (1) | Havana | 2,271 nt | ||
| mRNA |
triob-201
(1)
|
Ensembl | 8,958 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers