Gene
stat4
- ID
- ZDB-GENE-030616-264
- Name
- signal transducer and activator of transcription 4
- Symbol
- stat4 Nomenclature History
- Previous Names
-
- si:by134g18.2
- si:by51f19.1
- si:dz182h3.3
- si:dz199m19.1
- si:dz73o4.2
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within vasculogenesis. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Is expressed in anterior lateral plate mesoderm and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); genital herpes; and scleroderma (multiple). Orthologous to human STAT4 (signal transducer and activator of transcription 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Meng et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-stat4 | Meng et al., 2017 | |
| MO1-stat4 | N/A | Meng et al., 2017 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR013799 | STAT transcription factor, protein interaction |
| Domain | IPR013800 | STAT transcription factor, all-alpha domain |
| Domain | IPR013801 | STAT transcription factor, DNA-binding |
| Domain | IPR048988 | Signal transducer and activator of transcription, linker domain |
1 - 5 of 11 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription, linker domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8AW20 | InterPro | 667 | |||||||||||
| UniProtKB:A0A8M2BFB6 | InterPro | 732 | |||||||||||
| UniProtKB:A0A8M9QAM0 | InterPro | 694 | |||||||||||
| UniProtKB:B0S790 | InterPro | 731 |
1 - 4 of 4
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ottdart00000001760 (1) | Havana | 531 nt | ||
| mRNA | ottdart00000001847 (1) | Havana | 1,655 nt | ||
| mRNA | ottdart00000004046 (1) | Havana | 2,245 nt | ||
| mRNA |
stat4-201
(1)
|
Ensembl | 2,295 nt | ||
| mRNA |
stat4-202
(1)
|
Ensembl | 2,907 nt |
1 - 5 of 7 Show all
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196J1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-115D18 | ZFIN Curated Data | |
| Contained in | BAC | XX-113D7 | ZFIN Curated Data | |
| Contained in | BAC | IZAB-51F19 | ||
| Contained in | BAC | XX-BY134G18 | ||
| Contained in | PAC | BUSM1-46I22 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-73O4 | ||
| Contained in | PAC | BUSM1-182H3 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-199M19 | ||
| Contains | STS | chunp9518 |
1 - 10 of 12
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004510 (1) | 2295 nt | ||
| Genomic | GenBank:BX649377 (2) | 217898 nt | ||
| Polypeptide | UniProtKB:A0A8M2BFB6 (1) | 732 aa |
- Lin, J., Zhan, G., Liu, J., Maimaitiyiming, Y., Deng, Z., Li, B., Su, K., Chen, J., Sun, S., Zheng, W., Yu, X., He, F., Cheng, X., Wang, L., Shen, B., Yao, Z., Yang, X., Zhang, J., He, W., Wu, H., Naranmandura, H., Chang, K.J., Min, J., Ma, J., Björklund, M., Xu, P.F., Wang, F., Hsu, C.H. (2023) YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. National science review. 10:nwad227nwad227
- Luckner, B., Essfeld, F., Ayobahan, S.U., Richling, E., Eilebrecht, E., Eilebrecht, S. (2023) Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression. Ecotoxicology and environmental safety. 266:115570115570
- Gao, X., Yuan, Y.Y., Lin, Q.F., Xu, J.C., Wang, W.Q., Qiao, Y.H., Kang, D.Y., Bai, D., Xin, F., Huang, S.S., Qiu, S.W., Guan, L.P., Su, Y., Wang, G.J., Han, M.Y., Jiang, Y., Liu, H.K., Dai, P. (2018) Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal-dominant non-syndromic hearing loss.. Journal of Medical Genetics. 55(5):298-306
- Yang, F., Qiu, W., Li, R., Hu, J., Luo, S., Zhang, T., He, X., Zheng, C. (2018) Genome-wide identification of the interactions between key genes and pathways provide new insights into the toxicity of bisphenol F and S during early development in zebrafish. Chemosphere. 213:559-567
- Haarder, S., Kania, P.W., Holm, T.L., von Gersdorff Jørgensen, L., Buchmann, K. (2017) Effect of ES-products from Anisakis (Nematoda: Anisakidae) on experimentally induced colitis in adult zebrafish. Parasite immunology. 39(10)
- Mehrdana, F., Kania, P.W., Nazemi, S., Buchmann, K. (2017) Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model. PLoS One. 12:e0181277
- Meng, Z.Z., Liu, W., Xia, Y., Yin, H.M., Zhang, C.Y., Su, D., Yan, L.F., Gu, A.H., Zhou, Y. (2017) The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors. Nature communications. 8:14640
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zheng, W., Xu, H., Lam, S.H., Luo, H., Karuturi, R.K., and Gong, Z. (2013) Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One. 8(1):e53562
- Liongue, C., O'Sullivan. L.A., Trengove, M.C., and Ward, A.C. (2012) Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One. 7(3):e32777
1 - 10 of 14
Show