Gene
itsn1
- ID
- ZDB-GENE-030616-226
- Name
- intersectin 1 (SH3 domain protein)
- Symbol
- itsn1 Nomenclature History
- Previous Names
-
- si:dz173a8.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable molecular adaptor activity. Predicted to be involved in clathrin-dependent synaptic vesicle endocytosis. Predicted to act upstream of or within endocytosis and intracellular signal transduction. Predicted to be located in cell projection and synapse. Predicted to be active in cytoplasm; intracellular vesicle; and presynaptic membrane. Is expressed in head. Orthologous to human ITSN1 (intersectin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Dergai et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013693Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15350 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa25652 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32751 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | Dbl homology (DH) domain superfamily | Dbl homology domain | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | EH domain | Endocytic & GEF Adapter | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | Intersectin-1, AP2 binding region | PH-like domain superfamily | Pleckstrin homology domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BIA8 | InterPro | 1250 | |||||||||||||||
| UniProtKB:Q8JFT4 | InterPro | 1721 | |||||||||||||||
| UniProtKB:A0A8M2BI58 | InterPro | 1746 | |||||||||||||||
| UniProtKB:A0A8M2BIP7 | InterPro | 1751 | |||||||||||||||
| UniProtKB:A0AB32SZE1 | InterPro | 1803 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-287J19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-22N8 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-69G10 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-173A8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_207182 (1) | 5197 nt | ||
| Genomic | GenBank:BX005416 (1) | 163197 nt | ||
| Polypeptide | UniProtKB:A0AB32T1P8 (1) | 1808 aa |
- Ciampi, L., Mantica, F., López-Blanch, L., Permanyer, J., Rodriguez-Marín, C., Zang, J., Cianferoni, D., Jiménez-Delgado, S., Bonnal, S., Miravet-Verde, S., Ruprecht, V., Neuhauss, S.C.F., Banfi, S., Carrella, S., Serrano, L., Head, S.A., Irimia, M. (2022) Specialization of the photoreceptor transcriptome by Srrm3-dependent microexons is required for outer segment maintenance and vision. Proceedings of the National Academy of Sciences of the United States of America. 119:e2117090119
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Dergai, M., Tsyba, L., Dergai, O., Zlatskii, I., Skrypkina, I., Kovalenko, V., and Rynditch, A. (2010) Microexon-based regulation of ITSN1 and Src SH3 domains specificity relies on introduction of charged amino acids into the interaction interface. Biochemical and Biophysical Research Communications. 399(2):307-312
- Schebesta, M., and Serluca, F.C. (2009) olig1 expression identifies developing oligodendrocytes in zebrafish and requires hedgehog and notch signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(4):887-898
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
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