Gene
mhc2d8.35b2
- ID
- ZDB-GENE-030616-171
- Name
- major histocompatibility complex class II d8.35b2
- Symbol
- mhc2d8.35b2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to be involved in antigen processing and presentation and immune response. Predicted to localize to MHC class II protein complex and integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); bacterial infectious disease (multiple); bone inflammation disease (multiple); cellulitis (multiple); and eye disease (multiple). Orthologous to several human genes including HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2) and HLA-DRB5 (major histocompatibility complex, class II, DR beta 5).
- Genome Resources
- Note
-
novel protein similar to MHC class II beta chain
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000353 | MHC class II, beta chain, N-terminal |
| Domain | IPR003597 | Immunoglobulin C1-set |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Family | IPR050160 | Major Histocompatibility Complex/Immunoglobulin |
| Homologous_superfamily | IPR011162 | MHC classes I/II-like antigen recognition protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014745 | MHC class II, alpha/beta chain, N-terminal |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin C1-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Major Histocompatibility Complex/Immunoglobulin | MHC classes I/II-like antigen recognition protein | MHC class II, alpha/beta chain, N-terminal | MHC class II, beta chain, N-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AVD1
|
186 | ||||||||
|
UniProtKB:A0A0R4IRA8
|
277 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mhc2d8.35b2-201
(1)
|
Ensembl | 1,044 nt | ||
| mRNA |
mhc2d8.35b2-202
(1)
|
Ensembl | 1,019 nt | ||
| mRNA | ottdart00000001573 (1) | Havana | 754 nt |
Interactions and Pathways
No data available
Plasmids
No data available