Gene
cnp
- ID
- ZDB-GENE-030521-29
- Name
- 2'',3''-cyclic nucleotide 3'' phosphodiesterase
- Symbol
- cnp Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Acts upstream of or within axon regeneration. Located in cytosol. Is expressed in several structures, including axis; cardiovascular system; central nervous system; hindbrain neural plate; and neural tube. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to human CNP (2',3'-cyclic nucleotide 3' phosphodiesterase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb662 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023935Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypomyelinating leukodystrophy 20 | Alliance | ?Leukodystrophy, hypomyelinating, 20 | 619071 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclic nucleotide phosphodiesterase | Cyclic nucleotide phosphodiesterase, catalytic domain | Cyclic phosphodiesterase |
|---|---|---|---|---|---|
| UniProtKB:A0A8M3B0U8 | InterPro | 424 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cnp-201
(1)
|
Ensembl | 2,934 nt | ||
| mRNA |
cnp-202
(1)
|
Ensembl | 642 nt | ||
| mRNA |
cnp-203
(1)
|
Ensembl | 910 nt | ||
| mRNA |
cnp-204
(1)
|
Ensembl | 751 nt | ||
| mRNA |
cnp-205
(1)
|
Ensembl | 502 nt | ||
| mRNA |
cnp-206
(1)
|
Ensembl | 910 nt | ||
| mRNA |
cnp-207
(1)
|
Ensembl | 445 nt | ||
| mRNA |
cnp-208
(1)
|
Ensembl | 849 nt | ||
| mRNA |
cnp-209
(1)
|
Ensembl | 5,423 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-158E11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-26L17 | ZFIN Curated Data | |
| Encodes | EST | cb662 | Thisse et al., 2001 | |
| Encodes | EST | fd21d08 | ||
| Encodes | EST | fd44a05 | ||
| Encodes | EST | fi35d08 | ||
| Encodes | EST | fi37a10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009299341 (1) | 2910 nt | ||
| Genomic | GenBank:BX901973 (2) | 226081 nt | ||
| Polypeptide | UniProtKB:A0A8M3B0U8 (1) | 424 aa |
- Bandla, A.C., Sheth, A.S., Zarate, S.M., Uskamalla, S., Hager, E.C., Villarreal, V.A., González-García, M., Ballestero, R.P. (2023) Enhancing structural plasticity of PC12 neurons during differentiation and neurite regeneration with a catalytically inactive mutant version of the zRICH protein. BMC Neuroscience. 24:4343
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Picton, L.D., Bertuzzi, M., Pallucchi, I., Fontanel, P., Dahlberg, E., Björnfors, E.R., Iacoviello, F., Shearing, P.R., El Manira, A. (2021) A spinal organ of proprioception for integrated motor action feedback. Neuron. 109(7):1188-1201.e7
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Pathi, S.S., Jose, S., Govindaraju, S., Conde, J.A., Romo, H.E., Chamakura, K.R., Claunch, C.J., Benito-Martín, A., Challa-Malladi, M., González-García, M., and Ballestero, R.P. (2012) zRICH, a protein induced during optic nerve regeneration in zebrafish, promotes neuritogenesis and interacts with tubulin. Brain research. 1474:29-39
- Larson, T.A., Gordon, T.N., Lau, H.E., and Parichy, D.M. (2010) Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation. Developmental Biology. 346(2):296-309
- Tiso, N., Filippi, A., Benato, F., Negrisolo, E., Modena, N., Vaccari, E., Driever, W., and Argenton, F. (2009) Differential expression and regulation of olig genes in zebrafish. The Journal of comparative neurology. 515(3):378-396
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