ZFIN is now using GRCz12tu for Genomic Data

Gene

cnp

ID

ZDB-GENE-030521-29

Name

2'',3''-cyclic nucleotide 3'' phosphodiesterase

Symbol

cnp Nomenclature History

Previous Names

CNPase (1)
cnpl
fd21d08
fi37a10
sb:cb662 (1)
si:ch73-158e11.4
wu:fd21d08
wu:fd44a05
wu:fi35d08
wu:fi37a10
zRICH (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Acts upstream of or within axon regeneration. Located in cytosol. Is expressed in several structures, including axis; cardiovascular system; central nervous system; hindbrain neural plate; and neural tube. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to human CNP (2',3'-cyclic nucleotide 3' phosphodiesterase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb662 (21 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cnp Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypomyelinating leukodystrophy 20	Alliance	?Leukodystrophy, hypomyelinating, 20	619071

Associated With cnp Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR047325	Cyclic nucleotide phosphodiesterase, catalytic domain
Family	IPR008431	Cyclic nucleotide phosphodiesterase
Homologous_superfamily	IPR009097	Cyclic phosphodiesterase

Domain Details Per Protein

Protein	Additional Resources	Length	Cyclic nucleotide phosphodiesterase	Cyclic nucleotide phosphodiesterase, catalytic domain	Cyclic phosphodiesterase
UniProtKB:A0A8M3B0U8	InterPro	424

Transcripts

Genome Browsers

NCBI Map Viewer

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cnp-201 (1) Ensembl	Ensembl	2,934 nt	Select Tool ZFIN BLAST
mRNA	cnp-202 (1) Ensembl	Ensembl	642 nt	Select Tool ZFIN BLAST
mRNA	cnp-203 (1) Ensembl	Ensembl	910 nt	Select Tool ZFIN BLAST
mRNA	cnp-204 (1) Ensembl	Ensembl	751 nt	Select Tool ZFIN BLAST
mRNA	cnp-205 (1) Ensembl	Ensembl	502 nt	Select Tool ZFIN BLAST
mRNA	cnp-206 (1) Ensembl	Ensembl	910 nt	Select Tool ZFIN BLAST
mRNA	cnp-207 (1) Ensembl	Ensembl	445 nt	Select Tool ZFIN BLAST
mRNA	cnp-208 (1) Ensembl	Ensembl	849 nt	Select Tool ZFIN BLAST
mRNA	cnp-209 (1) Ensembl	Ensembl	5,423 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations