Gene
zbtb10
- ID
- ZDB-GENE-030429-10
- Name
- zinc finger and BTB domain containing 10
- Symbol
- zbtb10 Nomenclature History
- Previous Names
-
- sb:cb299
- si:dkeyp-34f6.1
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anterior axial hypoblast; forerunner cell group; nervous system; neural tube; and presumptive telencephalon. Orthologous to human ZBTB10 (zinc finger and BTB domain containing 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb299 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028045Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa16074 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18611 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36867 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36868 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43307 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | BTB/POZ domain | SKP1/BTB/POZ domain superfamily | Zinc finger and BTB domain-containing | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|
|
UniProtKB:A5PMB0
|
580 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zbtb10-201
(1)
|
Ensembl | 2,267 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-34F6 | ZFIN Curated Data | |
| Encodes | EST | cb299 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128539 (1) | 1816 nt | ||
| Genomic | GenBank:BX957239 (1) | 182432 nt | ||
| Polypeptide | UniProtKB:A5PMB0 (1) | 580 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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