Gene
myo6b
- ID
- ZDB-GENE-030318-3
- Name
- myosin VIb
- Symbol
- myo6b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within detection of mechanical stimulus involved in sensory perception; neurogenesis; and retina development in camera-type eye. Predicted to be located in several cellular components, including clathrin-coated pit; filopodium; and ruffle membrane. Predicted to be part of myosin complex. Predicted to be active in actin cytoskeleton; endocytic vesicle; and ruffle. Is expressed in anterior macula and neuromast hair cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22 | 606346 |
| autosomal dominant nonsyndromic deafness 22 | Alliance | Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy | 606346 |
| autosomal recessive nonsyndromic deafness 37 | Alliance | Deafness, autosomal recessive 37 | 607821 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Domain | IPR032412 | Myosin VI, cargo binding domain |
| Domain | IPR036114 | Class VI myosin, motor domain |
| Domain | IPR049016 | Myosin VI, lever arm |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class VI myosin, motor domain | Kinesin motor domain superfamily | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin VI, cargo binding domain | Myosin VI, lever arm | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1N1X8
|
1267 | |||||||
|
UniProtKB:F1R4R9
|
1255 | |||||||
|
UniProtKB:A0A8M9P042
|
1267 | |||||||
|
UniProtKB:Q68RJ3
|
1267 | |||||||
|
UniProtKB:A0A8M9P8V8
|
1264 | |||||||
|
UniProtKB:E9QFU5
|
1252 |
Interactions and Pathways
No data available
Plasmids
No data available