ZFIN ID: ZDB-GENE-030219-98
Gene Name: TIAM Rac1 associated GEF 2a
Gene Symbol: tiam2a    Nomenclature History

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Previous Name: id:ibd5033

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have Rho guanyl-nucleotide exchange factor activity. Predicted to be involved in intracellular signal transduction and regulation of Rho protein signal transduction. Is expressed in somite and tail bud. Orthologous to human TIAM2 (TIAM Rac1 associated GEF 2).
Genome Resources: Alliance (1),  Gene:100334442 (1),  Ensembl(GRCz11):ENSDARG00000087780 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd5033]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH tiam2a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH tiam2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process intracellular signal transduction (more)
Cellular Component membrane (more)
Molecular Function guanyl-nucleotide exchange factor activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000219 Dbl homology (DH) domain
Conserved_site IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain IPR001478 PDZ domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR003116 Raf-like Ras-binding
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Domain IPR040655 TIAM1, CC-Ex domain
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tiam2a-201 (1)    Ensembl 6529
tiam2a-202 (1)    Ensembl 558
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tiam2a No data available
MARKER RELATIONSHIPS
tiam2a Contained in: [BAC] CH73-215H5 (1), CH73-284N17 (1)
tiam2a Encodes: [EST] ibd5033
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:XM_009293288 (1)
Genomic GenBank:CU694254 (1) 88129 bp
Select Tool
Polypeptide UniProtKB:A0A286Y9S9 (1) 1671 aa
Sequence Clusters UniGene:77450 (1)
Sequence Information (all 24)
ORTHOLOGY for tiam2a ( Chr: 17 )
CITATIONS (24)