ZFIN ID: ZDB-GENE-030219-100
Gene Name: diphthamide biosynthesis 2
Gene Symbol: dph2    Nomenclature History

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Previous Names: id:ibd5058, zgc:162269 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have transferase activity. Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Is expressed in brain; immature eye; somite; and tail bud. Orthologous to human DPH2 (diphthamide biosynthesis 2).
Genome Resources: Alliance (1),  Gene:562538 (1),  Ensembl(GRCz11):ENSDARG00000078077 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd5058]
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH dph2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH dph2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process peptidyl-diphthamide biosynthetic process from peptidyl-histidine (more)
Molecular Function transferase activity (more)
GO Terms (all 2)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR010014 Diphthamide synthesis DHP2
Family IPR016435 Diphthamide synthesis DPH1/DPH2
Homologous_superfamily IPR042263 Diphthamide synthesis DPH1/DPH2, domain 1
Homologous_superfamily IPR042264 Diphthamide synthesis DPH1/DPH2, domain 2
Homologous_superfamily IPR042265 Diphthamide synthesis DPH1/DPH2, domain 3
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dph2-201 (1)    Ensembl 2778
dph2-203 (1)    Ensembl 935
ncRNA dph2-003 (1)    Ensembl 597
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dph2 No data available
MARKER RELATIONSHIPS
dph2 Contained in: [BAC] DKEY-86L18 (1) (order this)
dph2 Encodes: [EST] ibd5058
[cDNA] MGC:162269 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001089397 (1) 1946 bp
Genomic GenBank:CT574559 (1) 110868 bp
Select Tool
Polypeptide UniProtKB:A4QN59 (1) 498 aa
Sequence Information (all 11)
ORTHOLOGY for dph2 ( Chr: 7 )
CITATIONS (19)