Gene

myh9b

ID
ZDB-GENE-030131-998
Name
myosin, heavy chain 9b, non-muscle
Symbol
myh9b Nomenclature History
Previous Names
  • myh91
  • myh9l1
  • myhz9 (1)
  • fb55d12
  • myo2hc9 (1)
  • wu:fb30g06
  • wu:fb55d12
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in actin filament bundle distribution; midbrain-hindbrain boundary morphogenesis; and regulation of cell shape. Predicted to localize to myosin complex. Is expressed in brain; ectoderm; epidermis; pectoral fin; and trunk. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and proteinuria. Orthologous to human MYH9 (myosin heavy chain 9).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 3 from Gutzman et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myh9b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 17 Alliance Deafness, autosomal dominant 17 603622
MYH-9 related disease Alliance Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss 155100
Associated With myh9b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain Myosin IQ motif-containing domain superfamily Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A2R8QIT8 1742
UniProtKB:F1QC64 1749
UniProtKB:F1QJK4 1686
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations