Gene
trip11
- ID
- ZDB-GENE-030131-9833
- Name
- thyroid hormone receptor interactor 11
- Symbol
- trip11 Nomenclature History
- Previous Names
-
- cb423 (1)
- sb:cb423
- sb:cb721
- wu:fb71d07
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi organization and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be active in Golgi apparatus. Is expressed in several structures, including anterior axial hypoblast; axial mesoderm; axis; hypochord; and nervous system. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in achondrogenesis type IA. Orthologous to human TRIP11 (thyroid hormone receptor interactor 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb423 (7 images)
- cb721 (31 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Liu et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7228 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35534 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35535 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35536 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35537 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35538 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35539 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-trip11 | Liu et al., 2022 | |
| MO1-trip11 | N/A | Liu et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| achondrogenesis type IA | Alliance | Achondrogenesis, type IA | 200600 |
| Odontochondrodysplasia 1 | 184260 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital heart disease | AB + MO1-trip11 | standard conditions | Liu et al., 2022 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000237 | GRIP domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | GRIP domain |
|---|---|---|---|
| UniProtKB:A0A8M1P007 | InterPro | 1984 | |
| UniProtKB:A0A8M9QN82 | InterPro | 1983 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trip11-201
(1)
|
Ensembl | 10,865 nt | ||
| mRNA |
trip11-202
(1)
|
Ensembl | 3,176 nt | ||
| mRNA |
trip11-203
(1)
|
Ensembl | 733 nt | ||
| mRNA |
trip11-204
(1)
|
Ensembl | 576 nt | ||
| mRNA |
trip11-205
(1)
|
Ensembl | 5,856 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-10A23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-71P21 | ZFIN Curated Data | |
| Encodes | EST | cb423 | Thisse et al., 2001 | |
| Encodes | EST | cb721 | Thisse et al., 2001 | |
| Encodes | EST | fb71d07 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001278703 (1) | 7382 nt | ||
| Genomic | GenBank:BX284673 | 171564 nt | ||
| Polypeptide | UniProtKB:A0A8M1P007 (1) | 1984 aa |
- Liu, S., Wei, W., Wang, P., Liu, C., Jiang, X., Li, T., Li, F., Wu, Y., Chen, S., Sun, K., Xu, R. (2022) LOF variants identifying candidate genes of laterality defects patients with congenital heart disease. PLoS Genetics. 18:e1010530e1010530
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Bergen, D.J.M., Stevenson, N.L., Skinner, R.E.H., Stephens, D.J., Hammond, C.L. (2017) The Golgi matrix protein giantin is required for normal cilia function in zebrafish. Biology Open. 6(8):1180-1189
- Zhou, S., Zhao, H., Thongda, W., Zhang, D., Su, B., Yu, D., Peatman, E., Li, C. (2016) Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Fish & shellfish immunology. 49:324-35
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Coimbra, R.S., Weil, D., Brottier, P., Blanchard, S., Levi, M., Hardelin, J.-P., Weissenbach, J., and Petit, C. (2002) A subtracted cDNA library from the zebrafish (Danio rerio) embryonic inner ear. Genome research. 12(6):1007-1011
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