Gene
abca1b
- ID
- ZDB-GENE-030131-9826
- Name
- ATP-binding cassette, sub-family A (ABC1), member 1B
- Symbol
- abca1b Nomenclature History
- Previous Names
-
- im:7136239
- sb:cb407
- wu:fa07e06
- zgc:171581
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable ATPase-coupled transmembrane transporter activity; phosphatidylcholine floppase activity; and phosphatidylserine floppase activity. Predicted to be involved in phospholipid efflux. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including hypochord; intestine; mesoderm; solid lens vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hypolipoproteinemia (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human ABCA1 (ATP binding cassette subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb407 (11 images)
- IMAGE:7136239 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary hypoalphalipoproteinemia 1 | Alliance | HDL deficiency, familial, 1 | 604091 |
| Tangier disease | Alliance | Tangier disease | 205400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR013525 | ABC-2 type transporter, transmembrane domain |
| Family | IPR026082 | ABC transporter A |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC-2 type transporter, transmembrane domain | ABC transporter A | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F2Y6
|
2282 | ||||||
|
UniProtKB:F8W2X9
|
2271 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
abca1b-201
(1)
|
Ensembl | 8,271 nt | ||
| mRNA |
abca1b-202
(1)
|
Ensembl | 8,390 nt | ||
| mRNA |
abca1b-203
(1)
|
Ensembl | 1,614 nt |
Interactions and Pathways
No data available
Plasmids
No data available