Gene
hkdc1
- ID
- ZDB-GENE-030131-9801
- Name
- hexokinase domain containing 1
- Symbol
- hkdc1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in several processes, including glucose 6-phosphate metabolic process; glycolytic process; and intracellular glucose homeostasis. Predicted to act upstream of or within carbohydrate metabolic process and phosphorylation. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including digestive system; endoderm; heart; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human HKDC1 (hexokinase domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb370 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22286 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42188 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42189 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42190 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 92 | Alliance | Retinitis pigmentosa 92 | 619614 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ATPase, nucleotide binding domain | Hexokinase | Hexokinase, binding site | Hexokinase, C-terminal | Hexokinase, N-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:B8A5H6 | InterPro | 919 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-226B20 | ZFIN Curated Data | |
| Encodes | EST | cb370 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001115125 (1) | 3316 nt | ||
| Genomic | GenBank:BX546482 (1) | 206949 nt | ||
| Polypeptide | UniProtKB:B8A5H6 (1) | 919 aa |
- Martínez, R., Tu, W., Eng, T., Allaire-Leung, M., Piña, B., Navarro-Martín, L., Mennigen, J.A. (2020) Acute and long-term metabolic consequences of early developmental Bisphenol A exposure in zebrafish (Danio rerio). Chemosphere. 256:127080
- Wang, X., Sun, S., Cao, X., Gao, J. (2020) Quantitative Phosphoproteomic Analysis Reveals the Regulatory Networks of Elovl6 on Lipid and Glucose Metabolism in Zebrafish. International Journal of Molecular Sciences. 21(8):
- Luo, J., Zhang, X., He, S., Lou, Q., Zhai, G., Shi, C., Yin, Z., Zheng, F. (2019) Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. Redox Biology. 28:101355
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Yang, B., Zhai, G., Gong, Y., Su, J., Han, D., Yin, Z., and Xie, S. (2017) Depletion of insulin receptors leads to β-cell hyperplasia in zebrafish. Science Bulletin. 62(7):486-492
- Yang, B.Y., Zhai, G., Gong, Y.L., Su, J.Z., Peng, X.Y., Shang, G.H., Han, D., Jin, J.Y., Liu, H.K., Du, Z.Y., Yin, Z., Xie, S.Q. (2017) Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. American journal of physiology. Endocrinology and metabolism. 315(1):E38-E51
- Gao, Y., Dai, Z., Shi, C., Zhai, G., Jin, X., He, J., Lou, Q., Yin, Z. (2016) Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish. Frontiers in endocrinology. 7:88
- Dai, Z., Wang, H., Jin, X., Wang, H., He, J., Liu, M., Yin, Z., Sun, Y., Lou, Q. (2015) Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. American journal of physiology. Endocrinology and metabolism. 308(10):E849-59
- González-Alvarez, R., Ortega-Cuellar, D., Hernández-Mendoza, A., Moreno-Arriola, E., Villaseñor-Mendoza, K., Gálvez-Mariscal, A., Pérez-Cruz, M.E., Morales-Salas, I., and Velázquez-Arellano, A. (2009) The hexokinase gene family in the zebrafish: Structure, expression, functional and phylogenetic analysis. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 152(2):189-195
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