Gene
gsna
- ID
- ZDB-GENE-030131-9653
- Name
- gelsolin a
- Symbol
- gsna Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within actin filament capping and cell projection organization. Predicted to be located in cytoskeleton. Predicted to be active in actin cytoskeleton; cytoplasm; and extracellular space. Is expressed in several structures, including cardiovascular system; digestive system; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb107 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Finnish type amyloidosis | Alliance | Amyloidosis, Finnish type | 105120 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ADF-H/Gelsolin-like domain superfamily | Gelsolin-like domain | Villin/Gelsolin |
|---|---|---|---|---|---|
| UniProtKB:F1QUM3 | InterPro | 729 | |||
| UniProtKB:A0A8M9P366 | InterPro | 738 |
Interactions and Pathways
No data available
Plasmids
No data available