ZFIN is now using GRCz12tu for Genomic Data
Gene
lztr1
- ID
- ZDB-GENE-030131-9564
- Name
- leucine zipper like post translational regulator 1
- Symbol
- lztr1 Nomenclature History
- Previous Names
-
- fj87c05
- si:dkey-98f17.2 (1)
- wu:fj87c05
- zgc:158250
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in negative regulation of Ras protein signal transduction. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in Golgi apparatus and recycling endosome membrane. Used to study Noonan syndrome. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); glioblastoma; hepatocellular carcinoma; neurilemmoma; and schwannomatosis (multiple). Orthologous to human LZTR1 (leucine zipper like post translational regulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Nakagama et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Noonan syndrome 2 | Alliance | Noonan syndrome 2 | 605275 |
| Noonan syndrome 10 | Alliance | Noonan syndrome 10 | 616564 |
| schwannomatosis 2 | Alliance | {Schwannomatosis-2, susceptibility to} | 615670 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Noonan syndrome | lztr1zf3274/zf3274 (AB) | standard conditions | Nakagama et al., 2019 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/POZ domain | Kelch repeat type 1 | Kelch-type beta propeller | LZTR1/Attractin | SKP1/BTB/POZ domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A1L1Q7 | InterPro | 776 | |||||
| UniProtKB:A0A8M1NBN9 | InterPro | 783 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers