Gene

stat6

ID

ZDB-GENE-030131-9359

Name

signal transducer and activator of transcription 6, interleukin-4 induced

Symbol

stat6 Nomenclature History

Previous Names

sb:eu508
wu:fj66g07

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within granuloma formation and innate immune response. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; hematopoietic system; integument; kidney; and telencephalon. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lipoid nephrosis; prostate carcinoma; rectum adenocarcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu508 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stat6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hyper-IgE syndrome 6, autosomal dominant, with recurrent infections	620532

Associated With stat6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000980	SH2 domain
Domain	IPR013799	STAT transcription factor, protein interaction
Domain	IPR013800	STAT transcription factor, all-alpha domain
Domain	IPR013801	STAT transcription factor, DNA-binding
Domain	IPR035857	STAT6, SH2 domain
Domain	IPR048988	Signal transducer and activator of transcription, linker domain
Family	IPR001217	Transcription factor STAT
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR012345	STAT transcription factor, DNA-binding, N-terminal
Homologous_superfamily	IPR015988	STAT transcription factor, coiled coil
Homologous_superfamily	IPR036535	STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	p53-like transcription factor, DNA-binding domain superfamily	SH2 domain	SH2 domain superfamily	Signal transducer and activator of transcription, linker domain	STAT6, SH2 domain	STAT transcription factor, all-alpha domain	STAT transcription factor, coiled coil	STAT transcription factor, DNA-binding	STAT transcription factor, DNA-binding, N-terminal	STAT transcription factor, N-terminal domain superfamily	STAT transcription factor, protein interaction	Transcription factor STAT
UniProtKB:B3DGV1 InterPro	758

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	stat6-201 (1) Ensembl	Ensembl	3,221 nt	Select Tool ZFIN BLAST
mRNA	stat6-202 (1) Ensembl	Ensembl	1,973 nt	Select Tool ZFIN BLAST
mRNA	stat6-204 (1) Ensembl	Ensembl	961 nt	Select Tool ZFIN BLAST
ncRNA	stat6-003 (1) Ensembl	Ensembl	794 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations