Gene
septin2
- ID
- ZDB-GENE-030131-911
- Name
- septin 2
- Symbol
- septin2 Nomenclature History
- Previous Names
-
- sept2
- nedd5 (1)
- wu:fb52g01
- wu:fb99a01
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cilium assembly; cytoskeleton-dependent cytokinesis; and protein localization. Predicted to act upstream of or within cell division. Predicted to be located in several cellular components, including ciliary membrane; cleavage furrow; and midbody. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Is expressed in artery; notochord; and vein. Orthologous to human SEPTIN2 (septin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6891861 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa32902 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Septin | Septin 2 | Septin-type guanine nucleotide-binding (G) domain |
|---|---|---|---|---|---|---|
| UniProtKB:F1QQN9 | InterPro | 369 | ||||
| UniProtKB:A0A8M3B088 | InterPro | 356 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-105D4 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-472H7 | ZFIN Curated Data | |
| Contains | SNP | rs3727621 | ZFIN Curated Data | |
| Encodes | EST | fb52g01 | ||
| Encodes | EST | fb99a01 | ||
| Encodes | EST | IMAGE:2640115 | ||
| Encodes | EST | IMAGE:6891861 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001301360 (1) | 2299 nt | ||
| Genomic | GenBank:BX897733 (1) | 115031 nt | ||
| Polypeptide | UniProtKB:F1QQN9 (1) | 369 aa |
- Torraca, V., Bielecka, M.K., Gomes, M.C., Brokatzky, D., Busch-Nentwich, E.M., Mostowy, S. (2023) Zebrafish null mutants of Sept6 and Sept15 are viable but susceptible to Shigella infection. Cytoskeleton (Hoboken, N.J.). 80(7-8):266-274
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lemeer, S., Pinkse, M.W., Mohammed, S., van Breukelen, B., den Hertog, J., Slijper, M., and Heck, A.J. (2008) Online Automated in Vivo Zebrafish Phosphoproteomics: From Large-Scale Analysis Down to a Single Embryo. Journal of Proteome Research. 7(4):1555-1564
- Cao, L., Ding, X., Yu, W., Yang, X., Shen, S., and Yu, L. (2007) Phylogenetic and evolutionary analysis of the septin protein family in metazoan. FEBS letters. 581(28):5526-5532
- Pan, F., Malmberg, R.L., and Momany, M. (2007) Analysis of septins across kingdoms reveals orthology and new motifs. BMC Evolutionary Biology. 7(1):103
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Woods, I.G., Kelly, P.D., Chu, F., Ngo-Hazelett, P., Yan, Y.-L., Huang, H., Postlethwait, J.H., and Talbot, W.S. (2000) A comparative map of the zebrafish genome. Genome research. 10(12):1903-1914
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