Gene
myl12.2
- ID
- ZDB-GENE-030131-9028
- Name
- myosin, light chain 12, genome duplicate 2
- Symbol
- myl12.2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable myosin heavy chain binding activity. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm. Orthologous to human MYL12A (myosin light chain 12A) and MYL12B (myosin light chain 12B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chen et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023583Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028787Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Myosin regulatory light chain |
|---|---|---|---|---|---|
|
UniProtKB:B3DKC6
|
172 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myl12.2-201
(1)
|
Ensembl | 893 nt | ||
| mRNA |
myl12.2-202
(1)
|
Ensembl | 841 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(cxcr4b:myl12.2-mNeonGreen,myl7:mScarlet) |
|
| 1 | Qian et al., 2023 | |
| TgBAC(cxcr4b:myl12.2-mScarlet,myl7:mScarlet) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-216E9 | ZFIN Curated Data | |
| Encodes | EST | fa97a12 | ||
| Encodes | cDNA | MGC:195197 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001291711 (1) | 923 nt | ||
| Genomic | GenBank:AL929096 (2) | 192592 nt | ||
| Polypeptide | UniProtKB:B3DKC6 (1) | 172 aa |
No data available
- Dong, Y., Lu, R., Cao, H., Zhang, J., Wu, X., Deng, Y., Li, J.D. (2024) Deficiency in Prader-Willi syndrome gene necdin leads to attenuated cardiac contractility. iScience. 27:109974109974
- Qian, W., Yamaguchi, N., Lis, P., Cammer, M., Knaut, H. (2023) Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Current biology : CB. 34(2):245-259.e8
- Yamaguchi, N., Zhang, Z., Schneider, T., Wang, B., Panozzo, D., Knaut, H. (2022) Rear traction forces drive adherent tissue migration in vivo. Nature cell biology. 24:194-204
- Garcia de la Serrana, D., Wreggelsworth, K., Johnston, I.A. (2018) Duplication of a Single myhz1.1 Gene Facilitated the Ability of Goldfish (Carassius auratus) to Alter Fast Muscle Contractile Properties With Seasonal Temperature Change. Frontiers in Physiology. 9:1724
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Kassahn, K.S., Dang, V.T., Wilkins, S.J., Perkins, A.C., and Ragan, M.A. (2009) Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates. Genome research. 19(8):1404-1418
- Chen, Z., Huang, W., Dahme, T., Rottbauer, W., Ackerman, M.J., and Xu, X. (2008) Depletion of Zebrafish Essential and Regulatory Myosin Light Chains Reduces Cardiac Function Through Distinct Mechanisms. Cardiovascular research. 79(1):97-108
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