Gene

gria4b

ID

ZDB-GENE-030131-8013

Name

glutamate receptor, ionotropic, AMPA 4b

Symbol

gria4b Nomenclature History

Previous Names

glur4b
fj46g06
wu:fj46g06

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have AMPA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to localize to AMPA glutamate receptor complex; dendritic spine; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in schizophrenia. Is expressed in nervous system; otic vesicle; and ventral mandibular arch. Orthologous to human GRIA4 (glutamate ionotropic receptor AMPA type subunit 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu260 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gria4b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with or without seizures and gait abnormalities	617864

Associated With gria4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001320	Ionotropic glutamate receptor, C-terminal
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR019594	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family	IPR001508	Ionotropic glutamate receptor, metazoa
Family	IPR015683	Ionotropic glutamate receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I

Domain Details Per Protein

Protein	Length	Ionotropic glutamate receptor	Ionotropic glutamate receptor, C-terminal	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain	Ionotropic glutamate receptor, metazoa	Periplasmic binding protein-like I	Receptor, ligand binding region
UniProtKB:A0A8M9PTQ5 InterPro	433
UniProtKB:A0A8M9PI52 InterPro	815
UniProtKB:Q71E58 InterPro	904
UniProtKB:A0A8M9PQA5 InterPro	904
UniProtKB:A0A8M9PCI3 InterPro	904
UniProtKB:F1QBT6 InterPro	904
UniProtKB:A0A8M9P377 InterPro	904