Gene
neo1b
- ID
- ZDB-GENE-131121-320
- Name
- neogenin 1b
- Symbol
- neo1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to be involved in axon guidance; cell-cell adhesion; and neuron migration. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Orthologous to human NEO1 (neogenin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Brown et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-neo1b | Brown et al., 2019 | |
| CRISPR2-neo1b | Brown et al., 2019 | |
| CRISPR3-neo1b | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Neogenin, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q8A4 | InterPro | 143 | |||||||||
| UniProtKB:E7F004 | InterPro | 1413 | |||||||||
| UniProtKB:A0A8M3B6X0 | InterPro | 1432 | |||||||||
| UniProtKB:A0A8M6YW07 | InterPro | 1413 | |||||||||
| UniProtKB:A0A8M6YWL9 | InterPro | 1394 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-254L20 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-116K13 | ZFIN Curated Data | |
| Encodes | EST | fj41a03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009297706 (1) | 6358 nt | ||
| Genomic | GenBank:CR361563 (2) | 150089 nt | ||
| Polypeptide | UniProtKB:A0A8M3B6X0 (1) | 1432 aa |
- Comparative Orthology
- Alliance
- Höijer, I., Emmanouilidou, A., Östlund, R., van Schendel, R., Bozorgpana, S., Tijsterman, M., Feuk, L., Gyllensten, U., den Hoed, M., Ameur, A. (2022) CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations. Nature communications. 13:627
- von der Heyde, B., Emmanouilidou, A., Mazzaferro, E., Vicenzi, S., Höijer, I., Klingström, T., Jumaa, S., Dethlefsen, O., Snieder, H., de Geus, E., Ameur, A., Ingelsson, E., Allalou, A., Brooke, H.L., den Hoed, M. (2020) Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach. Scientific Reports. 10:11831
- Brown, S., Jayachandran, P., Negesse, M., Olmo, V., Vital, E., Brewster, R. (2019) Rgma-induced Neo1 proteolysis promotes neural tube morphogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(38):7465-7484
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, J., Wu, Y., Zhao, F., Wu, Y., Dong, W., Zhao, J., Zhu, Z., Liu, D. (2015) Fgf-signaling-dependent sox9a and atoh1a regulate otic neural development in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:234-44
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