Gene
ppfia2
- ID
- ZDB-GENE-030131-7905
- Name
- PTPRF interacting protein alpha 2
- Symbol
- ppfia2 Nomenclature History
- Previous Names
-
- fj39h11
- si:ch211-107n23.1
- wu:fj39h11
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to be involved in synapse organization. Predicted to be located in cytoplasm. Predicted to be active in presynaptic active zone. Orthologous to human PPFIA2 (PTPRF interacting protein alpha 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028996Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2166 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31397 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33462 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | LAR-interacting protein, Liprin | Liprin-alpha, SAM domain repeat 1 | Liprin-alpha, SAM domain repeat 2 | Liprin-alpha, SAM domain repeat 3 | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BC84 | InterPro | 1258 | ||||||
| UniProtKB:A0A8M3ARR0 | InterPro | 1274 | ||||||
| UniProtKB:A0A8M3B1S9 | InterPro | 1273 | ||||||
| UniProtKB:A0A8M3AYV1 | InterPro | 1248 | ||||||
| UniProtKB:A0A8M9Q5Z2 | InterPro | 1257 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppfia2-201
(1)
|
Ensembl | 3,713 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-107N23 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-9A20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-205C7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-231A18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-278E24 | ZFIN Curated Data | |
| Encodes | EST | fj39h11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045111 (1) | 3711 nt | ||
| Genomic | GenBank:BX537162 (1) | 223816 nt | ||
| Polypeptide | UniProtKB:A0A8M3ARR0 (1) | 1274 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, C., Hu, J., Qu, C., Wang, L., Huang, G., Niu, P., Zhong, Z., Hong, F., Wang, G., Postlethwait, J.H., Wang, H. (2015) Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Scientific Reports. 5:8113
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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