Gene

twf2a

ID
ZDB-GENE-030131-7638
Name
twinfilin actin-binding protein 2a
Symbol
twf2a Nomenclature History
Previous Names
  • twf1l
  • ptk9l (1)
  • zgc:91817
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to be involved in actin filament depolymerization; barbed-end actin filament capping; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within negative regulation of actin filament polymerization. Predicted to be located in cytoskeleton and perinuclear region of cytoplasm. Predicted to be active in actin filament and myofibril. Is expressed in lateral line ganglion; myotome; pectoral fin musculature; pharyngeal arch; and somite.
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa16143Allele with one point mutationUnknownSplice Site, Premature StopENU
sa26804Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-wdr82,twf2aN/AHuang et al., 2013
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Human Disease
Associated With twf2a Human Ortholog
No data available
Associated With twf2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002108 Actin-depolymerising factor homology domain
Family IPR028458 Twinfilin
Homologous_superfamily IPR029006 ADF-H/Gelsolin-like domain superfamily
Domain Details Per Protein
Protein Additional Resources Length Actin-depolymerising factor homology domain ADF-H/Gelsolin-like domain superfamily Twinfilin
UniProtKB:Q6GMH3 InterPro 347
UniProtKB:A0A8M2BDE1 InterPro 352
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 6
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA twf2a-201 (1) Ensembl 2,650 nt
ncRNA twf2a-002 (1) Ensembl 834 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-241N17ZFIN Curated Data
Contained inBACDKEY-98D20ZFIN Curated Data
EncodescDNAMGC:91817ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTWF23
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseTwf29
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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