Gene

arl3b

ID
ZDB-GENE-030131-7518
Name
ADP ribosylation factor like GTPase 3b
Symbol
arl3b Nomenclature History
Previous Names
  • arl3
  • si:ch211-208d15.4
  • wu:fj22g05
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and microtubule binding activity. Involved in cilium assembly. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and photoreceptor connecting cilium. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in eye; kidney; and oocyte. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Orthologous to human ARL3 (ARF like GTPase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
a233Allele with one deletionUnknownUnknownCRISPR
sa6267Allele with one point mutationUnknownPremature StopENU
sa35344Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-arl3b (2)
CRISPR2-arl3b (2)
CRISPR3-arl3b (2)
CRISPR4-arl3b (2)
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Human Disease
Associated With arl3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
retinitis pigmentosa 83 Alliance Retinitis pigmentosa 83 618173
Joubert syndrome 35 618161
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Associated With arl3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding domain
Family IPR006689 Small GTPase superfamily, ARF/SAR type
Family IPR044612 ADP-ribosylation factor-like protein 2/3
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
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Domain Details Per Protein
Protein Length ADP-ribosylation factor-like protein 2/3 P-loop containing nucleoside triphosphate hydrolase Small GTPase superfamily, ARF/SAR type Small GTP-binding domain
UniProtKB:B2GR26 182
UniProtKB:Q1MTE5 182
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 12
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA arl3-201 (1) Ensembl 2,396 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanARL310
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseArl319
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
1 - 7 of 7
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