Gene

arl3b

ID

ZDB-GENE-030131-7518

Name

ADP ribosylation factor like GTPase 3b

Symbol

arl3b Nomenclature History

Previous Names

arl3
si:ch211-208d15.4
wu:fj22g05

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and microtubule binding activity. Involved in cilium assembly. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and photoreceptor connecting cilium. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in eye; kidney; and oocyte. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Orthologous to human ARL3 (ARF like GTPase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arl3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
retinitis pigmentosa 83	Alliance	Retinitis pigmentosa 83	618173
		Joubert syndrome 35	618161

Associated With arl3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005225	Small GTP-binding domain
Family	IPR006689	Small GTPase superfamily, ARF/SAR type
Family	IPR044612	ADP-ribosylation factor-like protein 2/3
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase