Gene
rsph4a
- ID
- ZDB-GENE-030131-7437
- Name
- radial spoke head component 4A
- Symbol
- rsph4a Nomenclature History
- Previous Names
-
- rshl3
- wu:fj17d05
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to be involved in axoneme assembly and cilium movement. Predicted to act upstream of or within cilium assembly and cilium movement involved in cell motility. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Predicted to be part of radial spoke. Predicted to be active in axoneme. Is expressed in midbrain; otic placode; pronephric duct; and spinal cord neural rod. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 11. Orthologous to several human genes including RSPH4A (radial spoke head component 4A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sedykh et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Han et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 11 | Alliance | Ciliary dyskinesia, primary, 11 | 612649 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR006802 | Radial spokehead-like protein |
Domain Details Per Protein
| Protein | Additional Resources | Length | Radial spokehead-like protein |
|---|---|---|---|
| UniProtKB:A0A8M1QHY3 | InterPro | 524 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rsph4a-201
(1)
|
Ensembl | 1,775 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-117B8 | ZFIN Curated Data | |
| Encodes | EST | fj17d05 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001923735 (1) | 1825 nt | ||
| Genomic | GenBank:CR759879 (2) | 110254 nt | ||
| Polypeptide | UniProtKB:A0A8M1QHY3 (1) | 524 aa |
- Han, X., Xie, H., Wang, Y., Zhao, C. (2018) Radial spoke proteins regulate otolith formation during early zebrafish development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(7):3984-3992
- Sedykh, I., TeSlaa, J.J., Tatarsky, R.L., Keller, A.N., Toops, K.A., Lakkaraju, A., Nyholm, M.K., Wolman, M.A., Grinblat, Y. (2016) Novel roles for the radial spoke head protein 9 in neural and neurosensory cilia. Scientific Reports. 6:34437
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Choksi, S.P., Babu, D., Lau, D., Yu, X., Roy, S. (2014) Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Development (Cambridge, England). 141:3410-9
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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