Gene
tnk1
- ID
- ZDB-GENE-030131-7427
- Name
- tyrosine kinase, non-receptor, 1
- Symbol
- tnk1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including peptidyl-tyrosine autophosphorylation; regulation of cell population proliferation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human TNK1 (tyrosine kinase non receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR015116 | Cdc42 binding domain-like |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR049587 | TNK(ACK)-like non-receptor tyrosine-protein kinases, SAM domain |
| Family | IPR050198 | Non-receptor tyrosine kinases involved in cell signaling |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR037085 | Cdc42 binding domain-like superfamily |
Domain Details Per Protein
| Protein | Length | Cdc42 binding domain-like | Cdc42 binding domain-like superfamily | Non-receptor tyrosine kinases involved in cell signaling | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | TNK(ACK)-like non-receptor tyrosine-protein kinases, SAM domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1NB85
|
733 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Based on amino acid similarity, Woods, et al. (2005. Genome Res. 15:1307-1314.) report this gene to be the ortholog of human TNK2. Subsequent analysis suggests it is the ortholog of human TNK1 and mouse Tnk1 based on amino acid similarity and conserved synteny.