Gene

rin2b

ID

ZDB-GENE-030131-7043

Name

Ras and Rab interactor 2b

Symbol

rin2b Nomenclature History

Previous Names

fk68e06
si:ch211-85n16.4
wu:fk68e06 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to act upstream of or within signal transduction. Predicted to be active in cytosol and endocytic vesicle. Orthologous to human RIN2 (Ras and Rab interactor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rin2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Macrocephaly, alopecia, cutis laxa, and scoliosis	613075

Associated With rin2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000159	Ras-associating domain
Domain	IPR000980	SH2 domain
Domain	IPR003123	VPS9 domain
Domain	IPR035868	Ras and Rab interactor 2, SH2 domain
Family	IPR045046	Vacuolar protein sorting-associated protein 9-like
Homologous_superfamily	IPR036860	SH2 domain superfamily
Homologous_superfamily	IPR037191	VPS9 domain superfamily

Domain Details Per Protein

Protein	Length	Ras and Rab interactor 2, SH2 domain	Ras-associating domain	SH2 domain	SH2 domain superfamily	Vacuolar protein sorting-associated protein 9-like	VPS9 domain	VPS9 domain superfamily
UniProtKB:A0A8M6Z153 InterPro	567
UniProtKB:A0A8M6YZM7 InterPro	899

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rin2-203 (1) Ensembl	Ensembl	1,359 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-85n16.4-201 (1) Ensembl	Ensembl	2,475 nt	Select Tool ZFIN BLAST
ncRNA	si:ch211-85n16.4-002 (1) Ensembl	Ensembl	487 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations