Gene
zgc:173742
- ID
- ZDB-GENE-030131-6489
- Name
- zgc:173742
- Symbol
- zgc:173742 Nomenclature History
- Previous Names
-
- fl27b11
- si:dkey-204j6.1
- wu:fl27b11 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; DNA topological change; and chromosome segregation. Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human TOP1MT (DNA topoisomerase I mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018521 | DNA topoisomerase I, active site |
| Domain | IPR008336 | DNA topoisomerase I, DNA binding, eukaryotic-type |
| Domain | IPR013499 | DNA topoisomerase I, eukaryotic-type |
| Domain | IPR013500 | DNA topoisomerase I, catalytic core, eukaryotic-type |
| Domain | IPR025834 | Topoisomerase I C-terminal domain |
| Domain | IPR048045 | DNA topoisomerase I, DNA-binding domain |
| Family | IPR001631 | DNA topoisomerase I |
| Family | IPR051062 | DNA topoisomerase IB |
| Homologous_superfamily | IPR011010 | DNA breaking-rejoining enzyme, catalytic core |
| Homologous_superfamily | IPR013030 | DNA topoisomerase I, DNA binding, N-terminal domain 2 |
| Homologous_superfamily | IPR013034 | DNA topoisomerase I, DNA binding, N-terminal domain 1 |
| Homologous_superfamily | IPR014711 | DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type |
| Homologous_superfamily | IPR014727 | DNA topoisomerase I, catalytic core, alpha/beta subdomain |
| Homologous_superfamily | IPR036202 | DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA breaking-rejoining enzyme, catalytic core | DNA topoisomerase I | DNA topoisomerase I, active site | DNA topoisomerase IB | DNA topoisomerase I, catalytic core, alpha/beta subdomain | DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type | DNA topoisomerase I, catalytic core, eukaryotic-type | DNA topoisomerase I, DNA-binding domain | DNA topoisomerase I, DNA binding, eukaryotic-type | DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily | DNA topoisomerase I, DNA binding, N-terminal domain 1 | DNA topoisomerase I, DNA binding, N-terminal domain 2 | DNA topoisomerase I, eukaryotic-type | Topoisomerase I C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BH93
|
735 | ||||||||||||||
|
UniProtKB:A0A8M9PVS7
|
735 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zgc:173742-201
(1)
|
Ensembl | 1,941 nt | ||
| mRNA |
zgc:173742-202
(1)
|
Ensembl | 673 nt | ||
| mRNA |
zgc:173742-203
(1)
|
Ensembl | 1,449 nt |
Interactions and Pathways
No data available
Plasmids
No data available