Gene
larp6a
- ID
- ZDB-GENE-030131-6403
- Name
- La ribonucleoprotein 6, translational regulator a
- Symbol
- larp6a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables RNA binding activity. Acts upstream of or within somitogenesis. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; mesenchymal cell; post-vent region; segmental plate; and trunk. Orthologous to human LARP6 (La ribonucleoprotein 6, translational regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu362 (5 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| kg139 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 1 of 1
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006630 | La-type HTH domain |
| Domain | IPR024642 | SUZ-C domain |
| Domain | IPR034880 | La-related protein 6, RNA recognition motif |
| Family | IPR002344 | Lupus La protein |
| Family | IPR045180 | La domain containing protein |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | La domain containing protein | La-related protein 6, RNA recognition motif | La-type HTH domain | Lupus La protein | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | SUZ-C domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PHD4 | InterPro | 485 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
larp6a-201
(1)
|
Ensembl | 1,877 nt | ||
| mRNA |
larp6a-202
(1)
|
Ensembl | 2,245 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199903 (1) | 2259 nt | ||
| Genomic | GenBank:CU651575 (1) | 36934 nt | ||
| Polypeptide | UniProtKB:Q6PHD4 (1) | 485 aa |
- Hau, H.T.A., Ogundele, O., Hibbert, A.H., Monfries, C.A.L., Exelby, K., Wood, N.J., Nevarez-Mejia, J., Carbajal, M.A., Fleck, R.A., Dermit, M., Mardakheh, F.K., Williams-Ward, V.C., Pipalia, T.G., Conte, M.R., Hughes, S.M. (2020) Maternal Larp6 controls oocyte development, chorion formation and elevation. Development (Cambridge, England). 147(4):
- Valdivieso, A., Ribas, L., Piferrer, F. (2019) Ovarian transcriptomic signatures of zebrafish females resistant to different environmental perturbations. Journal of experimental zoology. Part B, Molecular and developmental evolution. 332(3-4):55-68
- LeBert, D., Squirrell, J.M., Freisinger, C., Rindy, J., Golenberg, N., Frecentes, G., Gibson, A., Eliceiri, K.W., Huttenlocher, A. (2018) Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair.. eLIFE. 7:e30703
- Castro, J.M., Horn, D.A., Lewis, K.A. (2017) Recombinant expression and purification of the RNA-binding LARP6 proteins from fish genetic model organisms. Protein Expression and Purification. 134:147-153
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Choe, S.K., Zhang, X., Hirsch, N., Straubhaar, J., and Sagerström, C.G. (2011) A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Developmental Biology. 358(2):356-67
- Wang, Z., Glenn, H., Brown, C., Valavanis, C., Liu, J.X., Seth, A., Thomas, J.E., Karlstrom, R.O., and Schwartz, L.M. (2009) Regulation of muscle differentiation and survival by Acheron. Mechanisms of Development. 126(8-9):700-709
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 8 of 8
Show