Gene

plch2a

ID

ZDB-GENE-030131-6367

Name

phospholipase C, eta 2a

Symbol

plch2a Nomenclature History

Previous Names

fi61g08
si:ch211-251b21.2 (1)
wu:fi61g08 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have phosphatidylinositol phospholipase C activity. Predicted to be involved in inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Orthologous to human PLCH2 (phospholipase C eta 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plch2a Human Ortholog

No data available

Associated With plch2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR000008	C2 domain
Domain	IPR000909	Phosphatidylinositol-specific phospholipase C, X domain
Domain	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR002048	EF-hand domain
Domain	IPR015359	Phosphoinositide-specific phospholipase C, EF-hand-like domain
Domain	IPR046971	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2, EF-hand motif
Family	IPR001192	Phosphoinositide phospholipase C family
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily

Domain Details Per Protein

Protein	Length	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2, EF-hand motif	C2 domain	C2 domain superfamily	EF-Hand 1, calcium-binding site	EF-hand domain	EF-hand domain pair	PH-like domain superfamily	Phosphatidylinositol-specific phospholipase C, X domain	Phosphoinositide phospholipase C family	Phosphoinositide-specific phospholipase C, EF-hand-like domain	Phospholipase C, phosphatidylinositol-specific, Y domain	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily	Pleckstrin homology domain
UniProtKB:A0A8M3BC32 InterPro	1493
UniProtKB:A0A8M3AVJ7 InterPro	1043
UniProtKB:A0A8M3AVI1 InterPro	1557
UniProtKB:A0A8M6Z7W5 InterPro	1490
UniProtKB:A0A8M1PAP8 InterPro	1534
UniProtKB:A0A8M9QIE9 InterPro	954
UniProtKB:A0A8M9Q9G7 InterPro	958

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	plch2a-201 (1) Ensembl	Ensembl	6,142 nt	Select Tool ZFIN BLAST
mRNA	plch2a-202 (1) Ensembl	Ensembl	4,166 nt	Select Tool
ncRNA	plch2a-002 (1) Ensembl	Ensembl	942 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations