Gene
iars1
- ID
- ZDB-GENE-030131-6325
- Name
- isoleucyl-tRNA synthetase 1
- Symbol
- iars1 Nomenclature History
- Previous Names
-
- iars
- fi46h05
- wu:fi46h05
- zgc:63790 (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have isoleucine-tRNA ligase activity. Involved in regulation of sprouting angiogenesis. Is expressed in brain; head; neural rod; and somite. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Growth retardation, impaired intellectual development, hypotonia, and hepatopathy | 617093 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR002300 | Aminoacyl-tRNA synthetase, class Ia |
| Domain | IPR013155 | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding |
| Domain | IPR033709 | Isoleucyl tRNA synthetase type 2, anticodon-binding domain |
| Family | IPR002301 | Isoleucine-tRNA ligase |
| Family | IPR023586 | Isoleucine-tRNA ligase, type 2 |
| Homologous_superfamily | IPR009008 | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain |
| Homologous_superfamily | IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class Ia | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding | Aminoacyl-tRNA synthetase, class I, conserved site | Isoleucine-tRNA ligase | Isoleucine-tRNA ligase, type 2 | Isoleucyl tRNA synthetase type 2, anticodon-binding domain | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | Rossmann-like alpha/beta/alpha sandwich fold | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7UZX0
|
1271 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available