Gene
tep1
- ID
- ZDB-GENE-030131-6153
- Name
- telomerase-associated protein 1
- Symbol
- tep1 Nomenclature History
- Previous Names
-
- si:ch211-284o19.1
- si:rp71-1g18.6
- wu:fb19f02
- wu:fi36h03 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable telomerase RNA binding activity. Predicted to contribute to telomerase activity. Predicted to be involved in telomere maintenance via recombination. Predicted to be part of telomerase holoenzyme complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and stomach cancer. Orthologous to human TEP1 (telomerase associated protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150837 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR007111 | NACHT nucleoside triphosphatase |
| Domain | IPR008858 | TROVE domain |
| Domain | IPR025139 | Domain of unknown function DUF4062 |
| Domain | IPR041452 | APAF-1 helical domain |
| Domain | IPR045804 | Domain of unknown function DUF5920 |
| Family | IPR052652 | Telomerase Complex Component |
| Homologous_superfamily | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR036465 | von Willebrand factor A-like domain superfamily |
| Homologous_superfamily | IPR037214 | TROVE domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | APAF-1 helical domain | Domain of unknown function DUF4062 | Domain of unknown function DUF5920 | NACHT nucleoside triphosphatase | P-loop containing nucleoside triphosphate hydrolase | Quinoprotein alcohol dehydrogenase-like superfamily | Telomerase Complex Component | TROVE domain | TROVE domain superfamily | von Willebrand factor A-like domain superfamily | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AXG0 | InterPro | 2677 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance