Gene

rasa2

ID

ZDB-GENE-030131-5660

Name

RAS p21 protein activator 2

Symbol

rasa2 Nomenclature History

Previous Names

fi11g05
wu:fi11g05

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to act upstream of or within intracellular signal transduction and negative regulation of Ras protein signal transduction. Is expressed in margin. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human RASA2 (RAS p21 protein activator 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu960 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rasa2 Human Ortholog

No data available

Associated With rasa2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001562	Zinc finger, Btk motif
Conserved_site	IPR023152	Ras GTPase-activating protein, conserved site
Domain	IPR000008	C2 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR001936	Ras GTPase-activating domain
Domain	IPR037773	RASA2, PH domain
Family	IPR039360	Ras GTPase-activating protein
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	RASA2, PH domain	Ras GTPase-activating domain	Ras GTPase-activating protein	Ras GTPase-activating protein, conserved site	Rho GTPase activation protein	Zinc finger, Btk motif
UniProtKB:A0A8M6Z2T9 InterPro	823

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rasa2-201 (1) Ensembl	Ensembl	2,478 nt	Select Tool ZFIN BLAST
mRNA	rasa2-202 (1) Ensembl	Ensembl	2,487 nt	Select Tool ZFIN BLAST
mRNA	rasa2-203 (1) Ensembl	Ensembl	2,514 nt	Select Tool ZFIN BLAST
mRNA	rasa2-204 (1) Ensembl	Ensembl	2,475 nt	Select Tool ZFIN BLAST
mRNA	rasa2-205 (1) Ensembl	Ensembl	2,523 nt	Select Tool ZFIN BLAST
mRNA	rasa2-206 (1) Ensembl	Ensembl	2,433 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations