Gene
foxk2b
- ID
- ZDB-GENE-030131-5310
- Name
- forkhead box K2b
- Symbol
- foxk2b Nomenclature History
- Previous Names
-
- fa28c04
- si:ch211-262e15.1
- wu:fa28c04 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human FOXK2 (forkhead box K2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR000253 | Forkhead-associated (FHA) domain |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR047397 | Forkhead box protein K2, forkhead domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead-associated (FHA) domain | Forkhead box protein K2, forkhead associated domain | Forkhead box protein K2, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | SMAD/FHA domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FFM9 | InterPro | 597 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch211-262e15.1-201
(1)
|
Ensembl | 3,489 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-262E15 | ||
| Contained in | Fosmid | CH1073-236F5 | ZFIN Curated Data | |
| Encodes | EST | fa28c04 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001922821 (1) | 3454 nt | ||
| Genomic | GenBank:BX539347 (2) | 145986 nt | ||
| Polypeptide | UniProtKB:E7FFM9 (1) | 597 aa |
- Geng, F.S., de la Calle-Mustienes, E., Gómez-Skarmeta, J.L., Lister, R., Bogdanovic, O. (2020) Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos. microPublication. Biology. 2020:
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Toro, S., Wegner, J., Muller, M., Westerfield, M., and Varga, Z.M. (2009) Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis. Gene expression patterns : GEP. 9(4):200-208
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