Gene

irx3b

ID
ZDB-GENE-030131-525
Name
iroquois homeobox 3b
Symbol
irx3b Nomenclature History
Previous Names
  • ziro3b (1)
  • wu:fb36a07
  • zgc:76885 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in pronephric distal tubule development; pronephric duct morphogenesis; and pronephric nephron tubule epithelial cell differentiation. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; hindbrain neural keel; neural plate; neural rod; and pronephros. Orthologous to human IRX3 (iroquois homeobox 3).
Genome Resources
Note
None
Expression
All Expression Data
14 figures from 8 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irx3b Human Ortholog
No data available
Associated With irx3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003893 Iroquois-class homeodomain protein
Domain IPR008422 Homeobox KN domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox KN domain Homeobox-like domain superfamily Iroquois-class homeodomain protein
UniProtKB:Q6NY58 343
UniProtKB:F1Q7T5 343
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations